Jacksonville State vs Southeast Missouri State Series
Jacksonville State leads the series with Southeast Missouri State 13–3 across 16 meetings.
| MEETINGS | 16 |
| SERIES | Jacksonville State leads 13–3 |
| JACKSONVILLE STATE WINS | 13 |
| SOUTHEAST MISSOURI STATE WINS | 3 |
| STREAK | Jacksonville State won the last meeting |
| LAST MEETING | Jacksonville State 21, Southeast Missouri State 3 · 2020 |
| FIRST ON RECORD | Jacksonville State 22, Southeast Missouri State 17 · 2003 |
