Southeast Missouri State vs Southern Illinois Series
Southern Illinois leads the series with Southeast Missouri State 14–6 across 20 meetings.
| MEETINGS | 20 |
| SERIES | Southern Illinois leads 14–6 |
| SOUTHEAST MISSOURI STATE WINS | 6 |
| SOUTHERN ILLINOIS WINS | 14 |
| STREAK | Southern Illinois won the last meeting |
| LAST MEETING | Southern Illinois 59, Southeast Missouri State 31 · 2025 |
| FIRST ON RECORD | Southern Illinois 28, Southeast Missouri State 7 · 2003 |
