| 2012 | Sep 29, 2012 | Louisville 21, Southern Miss 17 | M. M. Roberts Stadium · Hattiesburg, MS |
| 2010 | Dec 22, 2010 | Louisville 31, Southern Miss 28 · BEEF 'O' BRADY'S BOWL ST. PETERSBURG | – |
| 2009 | Oct 10, 2009 | Louisville 25, Southern Miss 23 | L&N Federal Credit Union Stadium · Louisville, KY |
| 2002 | Nov 14, 2002 | Louisville 20, Southern Miss 17 (2OT) (2OT) | M. M. Roberts Stadium · Hattiesburg, MS |
| 2001 | Oct 16, 2001 | Louisville 24, Southern Miss 14 | – |
| 2000 | Nov 4, 2000 | Louisville 49, Southern Miss 28 | – |
| 1999 | Nov 20, 1999 | Southern Miss 30, Louisville 27 | – |
| 1998 | Oct 10, 1998 | Southern Miss 56, Louisville 21 | – |
| 1997 | Oct 4, 1997 | Southern Miss 42, Louisville 24 | – |
| 1996 | Sep 28, 1996 | Southern Miss 24, Louisville 7 | – |
| 1995 | Oct 7, 1995 | Southern Miss 25, Louisville 21 | – |
| 1993 | Oct 16, 1993 | Louisville 35, Southern Miss 27 | – |
| 1991 | Sep 28, 1991 | Louisville 28, Southern Miss 14 | – |
| 1990 | Sep 29, 1990 | Southern Miss 25, Louisville 13 | – |
| 1989 | Oct 14, 1989 | Southern Miss 16, Louisville 10 | – |
| 1988 | Oct 1, 1988 | Southern Miss 30, Louisville 23 | – |
| 1987 | Oct 3, 1987 | Southern Miss 65, Louisville 6 | – |
| 1986 | Nov 22, 1986 | Southern Miss 31, Louisville 16 | – |
| 1985 | Oct 12, 1985 | Southern Miss 42, Louisville 12 | – |
| 1984 | Nov 17, 1984 | Southern Miss 34, Louisville 25 | – |
| 1983 | Nov 5, 1983 | Southern Miss 27, Louisville 3 | – |
| 1982 | Oct 23, 1982 | Southern Miss 48, Louisville 0 | – |
| 1981 | Nov 21, 1981 | Louisville 13, Southern Miss 10 | – |
| 1980 | Nov 22, 1980 | Louisville 6, Southern Miss 3 | – |
| 1979 | Nov 3, 1979 | Southern Miss 10, Louisville 10 | – |
| 1978 | Nov 18, 1978 | Southern Miss 37, Louisville 3 | – |
VS
