Eastern Illinois vs Southeast Missouri State Series
Southeast Missouri State leads the series with Eastern Illinois 12–10 across 22 meetings.
| MEETINGS | 22 |
| SERIES | Southeast Missouri State leads 12–10 |
| EASTERN ILLINOIS WINS | 10 |
| SOUTHEAST MISSOURI STATE WINS | 12 |
| STREAK | Southeast Missouri State won the last 8 |
| LAST MEETING | Southeast Missouri State 42, Eastern Illinois 13 · 2025 |
| FIRST ON RECORD | Southeast Missouri State 30, Eastern Illinois 17 · 2003 |
