Illinois State vs Southern Illinois Series
Southern Illinois leads the series with Illinois State 12–9 across 21 meetings.
| MEETINGS | 21 |
| SERIES | Southern Illinois leads 12–9 |
| ILLINOIS STATE WINS | 9 |
| SOUTHERN ILLINOIS WINS | 12 |
| STREAK | Southern Illinois won the last meeting |
| LAST MEETING | Southern Illinois 37, Illinois State 7 · 2025 |
| FIRST ON RECORD | Southern Illinois 45, Illinois State 17 · 2003 |
